Background:
@EN In the management of liver transplantation, massive blood loss, interruption of venous return to the heart, sudden infusion of acidic, cold and hyperkalemic blood from the graft, and uses of inotropic and vasoactive agents make cardiac
output(CO)
change unpredictably. We tried to find convenient method to estimate the change of CO by mixed venous oxygen saturation (SvO2)which can be monitored by pulmonary artery catheterization wit fiberoptic oximeter using a spectrophotometer. By
adapting
the
equation of oxygen transport and oxygen consumption (VO2), the equation CO(?)V/O2(Hb×0.134)×1/(SaO2-SvO) can be obtained. If we assume the VO2 and hemoglobin concentration is constant and hypoxemia is excluded, CO might be proportional to
1/(100-SvO2).
@ES Method:
@EN For the management of orthotopic liver transplantations in 5 mongrel dogs, we continuously monitored SvO2 with fiberoptic pulmonary catheter and intermittently measured the CO by thermodilution method accordingto operative phases. The
Pearson's
correlation coefficients between CO and mean arterial pressure. CO and SvO2 and 1/(100-SvO2) were measured in each dog.
@ES Result:
@EN The correlation coefficients between CO and 1/(100-SvO2) are raging from 0.74 to 0.98 with a corrected mean of 0.847 and significant in all dogs (p<0.05), and the correlation coefticients between CO and SvO2 are ranging from 0.67 to 0.96 with
a
corrected means of 0.786 and significant in 4 of 5 dogs.
@ES Conclusions;
@EN For the management of liver transplantation, the continuous monitoring mixed venous oxygen saturation by a fiberoptic pulmonary catheter is helpful to detect changes of cardiac output.
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